- What is cR and PR?
- What is best overall response rate?
- What does a stable scan mean?
- What does progression free survival mean?
- What does Recist mean?
- What is overall response rate?
- What does Orr mean in clinical trials?
- What is a partial response?
- What is PR in oncology?
- What is a target lesion?
- What is complete response?
- What is measurable disease?
- What is modified Recist?
- What is unequivocal progression?
- What is disease control rate?
- What does clinical response mean?
- What is SLD in Recist?
What is cR and PR?
pR: Residual tumor status based on the assessment of resected specimens by the pathologist.
cR: Residual tumor status based on the local resection and systemic findings..
What is best overall response rate?
Definition of Best Overall Tumor Response The Best Overall Response (BOR) is the best response recorded from the start of the study treatment until the disease progression/recurrence: Complete Response (CR) upon confirmation at least 4 wks of 1st CR. Partial Response (PR) upon confirmation at least 4 wks of first PR.
What does a stable scan mean?
Stable disease may mean that a treatment isn’t working, but it may also mean that a treatment is working very well. If a tumor was expected to have grown in the interval between two scans and has remained stable, it may mean that the treatment is effective, even if there is not much of a change seen on imaging.
What does progression free survival mean?
Progression-free survival (PFS) is “the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse”.
What does Recist mean?
Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve (“respond”), stay the same (“stabilize”), or worsen (“progress”) during treatment.
What is overall response rate?
Overall response rate (ORR) is defined as the proportion of patients who have a partial or complete response to therapy; it does not include stable disease and is a direct measure of drug tumoricidal activity.
What does Orr mean in clinical trials?
PFS is considered an indication of disease control and stabilization. Overall Response Rate (ORR) Overall response rate, or ORR, is the proportion of patients in a trial whose tumor is destroyed or significantly reduced by a drug.
What is a partial response?
A partial response or partial remission means the cancer partly responded to treatment, but still did not go away. A partial response is most often defined as at least a 50% reduction in measurable tumor. Here, when we refer to a remission it will generally mean a partial remission.
What is PR in oncology?
Partial Response, or PR – Signifies that decreases of at least 30% have been noted in the lesion that has the largest diameter, or LD.
What is a target lesion?
A target lesion is a round skin lesion with three concentric colour zones: A darker centre with a blister or crust. A ring around this that is paler pink and raised due to oedema (fluid swelling)
What is complete response?
Listen to pronunciation. (kum-PLEET reh-SPONTS) The disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured.
What is measurable disease?
Listen to pronunciation. (MEH-zur-uh-bul dih-ZEEZ) A tumor that can be accurately measured in size. This information can be used to judge response to treatment.
What is modified Recist?
Modified RECIST (mRECIST) criteria only concern hepatocellular carcinoma and only take into account the viable portion (enhanced after injection during the arterial phase).
What is unequivocal progression?
Unequivocal progression is defined in RECIST 1.1 by the following criteria: (a) in patients with measurable disease, an overall substantial enlargement of nontarget lesions that merits discontinuation of therapy, even in the presence of stable disease or partial response seen in target lesions; and (b) in patients …
What is disease control rate?
Disease Control Rate (DCR) and Clinical Benefit Rate (CBR) are defined as the percentage of patients with advanced or metastatic cancer who have achieved complete response, partial response and stable disease to a therapeutic intervention in clinical trials of anticancer agents.
What does clinical response mean?
Clinical response is also used as an indicator of therapeutic efficacy in combination with other indicators. Its value as a surrogate indicator of a survival benefit remains unclear in most instances and can hardly be established within the framework of a single randomised trial.
What is SLD in Recist?
RECIST 1.0 divides lesions into measurable and non-measurable lesions before the start of therapy . … The sum of the longest diameter of the target lesions (SLD) is calculated. At each time point, the same target lesions are to be measured.